Female ReproAdvancing Research and Ensuring Reproductive Health

Explore recent research and guidelines on factors impacting fertility, reproductive health, and aging in women.

Treating Polycystic Ovary Syndrome Early May Help Prevent Later Drop in Fertility
April 4, 2017 | In adolescent girls with polycystic ovary syndrome (PCOS), bringing the amount of abdominal visceral fat and liver fat down to normal restores ovulation, normalizes the symptoms…

New Natural Estrogen-Progesterone Capsule Reduces Postmenopausal Hot Flashes
April 3, 2017 | A natural, or bioidentical, combined estradiol-progesterone capsule (TX-001HR) significantly decreases the frequency and severity of moderate to severe hot flashes…

Alcohol Abuse Even Before Pregnancy May Harm Offspring
April 2, 2017 | Mothers who binge drink before they become pregnant may be more likely to have children with high blood sugar and other changes in glucose function…

Many Transgender Individuals Consider Their Fertility Important, Survey Shows
April 2, 2017 | Nearly one-fourth of transgender individuals in Toronto, Canada, regard their own fertility as important, but most lack knowledge regarding and access to reproductive options…

Decision-Tree Tool Can Help Screen Women with Gestational Diabetes for Sleep Apnea
April 1, 2017 | Healthcare providers can use a decision-tree tool to screen women who have gestational diabetes (GDM) for obstructive sleep apnea (OSA), new research from Thailand reports…

Endocrine Society Experts Issue Clinical Practice Guideline on Hypothalamic Amenorrhea
March 22, 2017 | Female athletes and women who have eating disorders are prone to developing a condition called hypothalamic amenorrhea that causes them to stop menstruating. The Endocrine Society today issued…

Tri-Point: The Genetics and Epigenetics of Puberty
January 2017 | In 2005, the editors of Science, celebrating the journal’s 125th anniversary, posed 125 unanswered questions that it predicted would fuel active research…

Survey: Endocrinologists Want Training in Transgender Care
January 10, 2017 | Four out of five physicians who specialize in treating hormone health conditions have never received formal training on care for transgender individuals, according to a new study published in the Endocrine Society’s Journal of Clinical Endocrinology & Metabolism

Women Dissatisfied with Long Process to Diagnose Polycystic Ovary Syndrome
December 1, 2016 | International survey finds many wait years for diagnosis of common reproductive, metabolic health problem. A large international survey of women with a common condition called…

Endocrine Society Meets with NIH Office of Research on Women’s Health to Discuss Research Gaps & Policy Priorities
December 2016 | On Thursday, December 1, Janine Austin Clayton, MD, director of the NIH Office of Research on Women’s Health (ORWH) and associate director of Women’s Health Research…

Explore highlights of current education across the Endocrine Society.

Gender-Affirming Endocrine Care of Transgender and Gender Non-Binary People
ENDO Session | No credit available
Guy G. T'Sjoen, MD, PhD
Are you prepared to deliver essential endocrine care to this under-served and often misunderstood patient population?

Transitions of Care: Turner Syndrome
Practice Resource | No credit available
Resources for you and your patients to facilitate the challenging transition from pediatric to adult endocrine practice.

Women’s Health Digital Toolkit
Patient Resource | No credit available
Reviewer: Genevieve S Neal-Perry, MD, PhD
Interactive and downloadable resources and information for patients with questions related to women’s health including menopause, bone loss, and estrogen.

Explore highlights of current publications across the Endocrine Society journals. Visit academic.oup.com/endocrinesociety for more.

Effects of Rapid Weight Loss on Systemic and Adipose Tissue Inflammation and Metabolism in Obese Postmenopausal Women
JES | April 25, 2017
Jose O. Aleman, Neil M. Iyengar, Jeanne M. Walker, Ginger L. Milne, Joel Correa Da Rosa, Yupu Liang, Dilip D. Giri, Xi Kathy Zhou, Michael N. Pollak, Clifford A. Hudis, Jan L. Breslow, Peter R. Holt, and Andrew J. Dannenberg
Obesity is associated with subclinical white adipose tissue inflammation, as defined by the presence of crown-like structures (CLSs) consisting of dead or dying adipocytes encircled by macrophages…

IGF1R Expression in Ovarian Granulosa Cells Is Essential for Steroidogenesis, Follicle Survival, and Fertility in Female Mice
Endocrinology | April 12, 2017
Sarah C. Baumgarten, Marah Armouti, CheMyong Ko, and Carlos Stocco
Infertility is a common medical problem affecting >10% of reproductive-aged women, of whom ~40% have ovulatory dysfunction. Ovulation results from the lengthy folliculogenesis process that …

Subcutaneous Injection of Testosterone Is an Effective and Preferred Alternative to Intramuscular Injection: Demonstration in Female-to-Male Transgender Patients
JCEM | April 3, 2017
Daniel I. Spratt, India I. Stewart, Clara Savage, Wendy Craig, Norman P. Spack, Donald Walt Chandler, Lindsey V. Spratt, Toni Eimicke, and Jerrold S. Olshan
Testosterone (T) therapy is commonly administered to hypogonadal men and female-to-male (FTM) transgender patients. Since its introduction in the 1930s, parenteral T has typically been administered intramuscularly…

Tissue-Specific Ablation of the LIF Receptor in the Murine Uterine Epithelium Results in Implantation Failure
Endocrinology | March 22, 2017
JrGang Cheng, Gracy Rosario, Tatiana V. Cohen, Jianbo Hu, and Colin L. Stewart
The cytokine leukemia inhibitory factor (LIF) is essential for rendering the uterus receptive for blastocyst implantation. In mice, LIF receptor expression (LIFR) is largely restricted…

Menopausal Hormone Therapy and Type 2 Diabetes Prevention: Evidence, Mechanisms, and Clinical Implications
Endocrine Reviews | March 8, 2017
Franck Mauvais-Jarvis, JoAnn E. Manson, John C. Stevenson, and Vivian A. Fonseca
Type 2 diabetes has reached epidemic proportions in the United States. Large, randomized controlled trials suggest that menopausal hormone therapy (MHT) delays the onset of type 2 diabetes in women…

From Pregnancy to Preeclampsia: A Key Role for Estrogens
Endocrine Reviews | March 3, 2017
Nadia Berkane, Philippe Liere, Jean-Paul Oudinet, Alexandre Hertig, Guillaume LeFevre, Nicola Pluchino, Michael Schumacher, and Nathalie Chabbert-Buffet
Preeclampsia (PE) occurs in 3% to 7% of pregnancies and is one of the main causes of maternal and fetal/neonatal morbidity and mortality…

Autocrine Prolactin Stimulates Endometrial Carcinoma Growth and Metastasis and Reduces Sensitivity to Chemotherapy
Endocrinology | February 15, 2017
Keshuo Ding, Yan Yuan, Qing-Yun Chong, Yulu Yang, Rui Li, Xiaoni Li, Xiangjun Kong, Pengxu Qian, Zirui Xiong, Vijay Pandey, Lan Ma, Zhengsheng Wu, Peter E. Lobie, and Tao Zhu
Advanced and recurrent endometrial carcinoma (EC) exhibits a poor response to chemotherapy and low survival rates. It has been previously reported that human prolactin (hPRL) is…

Whole-exome Sequencing for Diagnosis of Turner Syndrome: Towards Next Generation Sequencing and Newborn Screening
JCEM | January 24, 2017
David R. Murdock, Frank X. Donovan, Settara C. Chandrasekharapp, Nicole Banks, Carolyn Bondy, Maximilian Muenke, and Paul Kruszka
Context: Turner syndrome (TS) is due to a complete or partial loss of an X chromosome in females and is not currently part of newborn screening…

Maternal Cortisol During Pregnancy and Infant Adiposity: A Prospective Investigation
JCEM | December 23, 2016
Sonja Entringer, Claudia Buss, Jerod M. Rasmussen, Karen Lindsay, Daniel L. Gillen, Dan M. Cooper, and Pathik D. Wadhwa
Obesity represents one of the most urgent national and global health challenges because of its high prevalence and established health risks. Childhood obesity is a particularly grave concern…

Progesterone Receptors and Proliferation of the Endometrium in Obese Women With Polycystic Ovary Syndrome—A Lifestyle Intervention Study
JCEM | December 20, 2016
Mariana Paulson, Lena Sahlin, and Angelica Lindén Hirschberg
Polycystic ovary syndrome (PCOS) is a heterogeneous endocrine metabolic disorder. It affects about 10% of fertile age women and is characterized…

For a complete list of Endocrine Society guidelines, visit endocrine.org/guidelines.

Endocrine Treatment of Gender-Dysphoric/Gender-Incongruent Persons
JCEM | September 13, 2017
Wylie C Hembree, Peggy T Cohen-Kettenis, Louis Gooren, Sabine E Hannema, Walter J Meyer, M Hassan Murad, Stephen M Rosenthal, Joshua D Safer, Vin Tangpricha, and Guy G T’Sjoen
Gender affirmation is multidisciplinary treatment in which endocrinologists play an important role. Gender-dysphoric/gender-incongruent persons seek and/or are referred to endocrinologists…

Hypothalamic Amenorrhea
JCEM | March 22, 2017
Catherine M. Gordon, Kathryn E. Ackerman, Sarah L. Berga, Jay R. Kaplan, George Mastorakos, Madhusmita Misra, M. Hassan Murad, Nanette F. Santoro, and Michelle P. Warren
FHA is a form of chronic anovulation, not due to identifiable organic causes, but often associated with stress, weight loss, excessive exercise, or a combination thereof. Investigations should include assessment of systemic and endocrinologic etiologies…

Treatment of Symptoms of the Menopause
JCEM | October 7, 2015
Cynthia A. Stuenkel, Susan R. Davis, Anne Gompel, Mary Ann Lumsden, M. Hassan Murad, JoAnn V. Pinkerton, and Richard J. Santen
Menopausal hormone therapy (MHT) is the most effective treatment for vasomotor symptoms and other symptoms of the climacteric. Benefits may exceed risks for the majority…

Androgen Therapy in Women: A Reappraisal
JCEM | October 3, 2014
Margaret E. Wierman, Wiebke Arlt, Rosemary Basson, Susan R. Davis, Karen K. Miller, Mohammad H. Murad, William Rosner, and Nanette Santoro
We continue to recommend against making a diagnosis of androgen deficiency syndrome in healthy women because there is a lack of a well-defined syndrome, and…

Diagnosis and Treatment of Polycystic Ovary Syndrome
JCEM | November 20, 2013
Richard S. Legro, Silva A. Arslanian, David A. Ehrmann, Kathleen M. Hoeger, M. Hassan Murad, Renato Pasquali, and Corrine K. Welt
We suggest using the Rotterdam criteria for diagnosing PCOS (presence of two of the following criteria: androgen excess, ovulatory dysfunction, or polycystic ovaries). Establishing a…

Evaluation and Treatment of Hirsutism in Premenopausal Women
JCEM | January 14, 2009
Kathryn A. Martin, R. Jeffrey Chang, David A. Ehrmann, Lourdes Ibanez, Rogerio A. Lobo, Robert L. Rosenfield, Jerry Shapiro, Victor M. Montori, and Brian A. Swiglo
We suggest testing for elevated androgen levels in women with moderate or severe hirsutism or hirsutism of any degree when it is sudden in onset, rapidly progressive…

For additional meetings, visit the Endocrine Society’s Worldwide Endocrinology Calendar at endocrine.org/calendar.

Clinical Endocrinology Update & Endocrine Board Review
Dates: September 23–27, 2017
Location: Chicago, Illinois, United States
Sponsor: Endocrine Society
Whether you need the latest clinical information or you’re preparing to certify or recertify for the boards, Clinical Endocrinology Update (CEU) and Endocrine Board Review (EBR) have you covered.

ART World Congress
Dates: October 25–26, 2017
Sponsor: CME Congresses Ltd.
Location: New York, New York, United States

2017 American Society for Reproductive Medicine Congress and Expo
Dates: October 28 - November 1, 2017
Location: Washington, DC, United States
Sponsor: American Society for Reproductive Medicine